Caffeine Demethylation Monitoring Using a Transdermal Sweat Patch
نویسندگان
چکیده
منابع مشابه
Sweat testing in opioid users with a sweat patch.
For many years, toxicologists have detected the presence of drugs of abuse in biological materials using blood or urine. In recent years, remarkable advances in sensitive analytical techniques have enabled the analysis of drugs in unconventional samples such as sweat. In a study conducted in a detoxification center, sweat patches were applied to 20 known heroin abusers. Subjects wore the patch ...
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Transdermal patches are a popular route for drug delivery because of the sustained drug levels, low side effects, reduced hepatitic first-pass effect and ease of use, including self– administration. The basic components of any transdermal delivery system include one or more active pharmaceutical ingredient s (APIs) dissolved or dispersed in a reservoir or inert polymer matrix; an outer backing ...
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Transdermal drug delivery of ibuprofen, a well known NSAID has sparked considerable research interest in the recent years. The hydrophobic nature of the drug as well as its water insolubility is a significant deterrent for its uptake through the skin and its bioavailability at the targeted site of pain/inflammation. This work addresses both concerns through a novel microemulsion formulation syn...
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Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enz...
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In the present work, monolithic matrix transdermal systems containing Drug x were prepared using various ratios of the polymer blends of hydroxy propyl methyl cellulose (HPMC) and Eudragit S 100 (ES) with triethyl citrate as a plasticizer. A 32 full factorial design was employed. The concentration of HPMC and ES were used as independent variables, while percentage drug release was selected as d...
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ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 1998
ISSN: 1945-2403,0146-4760
DOI: 10.1093/jat/22.7.596